PIRE is an independent, nonprofit organization merging scientific knowledge and proven practice to create solutions that improve the health, safety and well-being of individuals, communities, and nations around the world.


PIRE has a significant national presence in the area of applied science, with funded research projects at its centers on prevention, treatment, and policy research. PIRE scientists and practitioners continually focus on the design and implementation of complex program evaluation strategies and the conduct of research related to health and social issues, and criminal justice. PIRE practitioners and scientists provide training and technical assistance in many health-related areas to states and communities that are attempting to improve public health.

PIRE has a rich blend of grant and contract funded work, ranging from primary research and program evaluation to service delivery (technical assistance and direct service). The diverse portfolio is guided by PIRE’s mission and commitment to the application of science for the public good. PIRE is conducting the 2013 National Roadside Survey of Alcohol and Drugged Driving principally funded by the National Highway Traffic Safety Administration (NHTSA). We also are conducting the nation’s first Case-Control Drug Crash Risk Study to measure the contribution of various drugs alone and in combination with alcohol to the risk of being involved in a crash. NHTSA has now funded PIRE to study in Colorado and Washington the effects of legalizing the recreational use of marijuana on the prevalence of marijuana-involved driving. Our emphasis on environmental prevention research funded by the National Institute of Alcohol and Alcohol Abuse (NIAAA) center grant, created the Prevention Research Center, now in its 31st year. The outcomes from the center grant have contributed significantly to the Office of Juvenile Justice and Delinquency Programs’ (OJJDP) Enforcement of Underage Drinking Laws (EUDL) program strategies over the last 17 years. These now widely accepted environmental strategies have been implemented in most states to address underage drinking. Below is a sampling of PIRE’s 180 domestic and international projects funded by over 40 agencies.


PIRE was founded as a 501(c) (3) organization in San Francisco, CA in 1974, when a group of allied scientists were among the first to recognize the dangers inherent in the emergence of widespread drug use. The Institute developed and disseminated some of the earliest prevention strategies. Since then, PIRE has broadened its scope to encompass many of the most serious threats to human health and safety.

Nonprofit Status

PIRE is a California-chartered, not-for-profit corporation, that qualifies for tax-exempt status under section 501(c)3 of the IRS code. Annual form 990s are available on this website.