PIRE is an independent, nonprofit organization merging scientific knowledge and proven practice to create solutions that improve the health, safety, and well-being of individuals, communities, and nations around the world.

The mission of PIRE is to promote, undertake, and evaluate activities, studies, and programs that improve individual and public health, welfare, and safety. In support of this mission, we create and support an environment within which skilled, innovative, and dedicated researchers and practitioners work to extend the leading edges of their respective fields. For over 43 years, PIRE has been awarded grant- and contract-funded work, ranging from primary research and program evaluation to service delivery (technical assistance and direct service)—guided by PIRE’s mission and commitment to the application of science for the public good.

Founded in 1974, PIRE has a longstanding reputation for research integrity. Funded with a balance of National Institutes of Health (NIH) grants, federal contracts, and foundation awards, we currently have over 50 active NIH awards. We have held a NIAAA Center Grant since 1980 with a robust Postdoctoral Training Program. We have primed multimillion dollar contracts with the Department of Defense, National Highway Traffic Safety Administration, Substance Abuse and Mental Health Services Administration, and Veterans Health Administration. We also have significant international NIH and contract work.

Today, PIRE has a significant national presence in the area of applied science, with funded research projects at its centers on prevention, treatment, and policy research. PIRE scientists and practitioners continually focus on the design and implementation of complex program evaluation strategies and the conduct of research related to health and social issues, and criminal justice. PIRE practitioners and scientists provide training and technical assistance in many health-related areas to states and communities that are attempting to improve public health.



PIRE was founded as a 501(c)(3) organization in San Francisco, CA, in 1974, when a group of allied scientists were among the first to recognize the dangers inherent in the emergence of widespread drug use. PIRE developed and disseminated some of the earliest prevention strategies. Since then, PIRE has broadened its scope to encompass many of the most serious threats to human health and safety.

Nonprofit Status

PIRE is a California-chartered, not-for-profit corporation, that qualifies for tax-exempt status under section 501(c)(3) of the IRS code. Annual form 990s are available on the Legal page.